2026
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MSK1 regulates BDNF-dependent MeCP2 phosphorylation and striatal circuit development. Varela-Andrés, N., et al. Molecular Psychiatry (Nature Portfolio). In press.
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Multisession epidural direct current stimulation of the auditory cortex mitigates age-related transcriptomic dysregulation in Wistar rats. Fernández Del Campo, IS., Cebrián-León, A., Hernández-del Caño, C., Varela-Andrés, N., Plaza, I., Deogracias, R., Merchán, MA. Hearing Research, 109580.
2024
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Neurotrophins and their receptors: BDNF´s role in GABAergic neurodevelopment and disease. Hernández-del Caño, C., Varela-Andrés, N., Cebrián-León, A., Deogracias, R. International Journal of Molecular Sciences 25 (15), 8312.
2023
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Enhanced TrkA signaling impairs basal forebrain-dependent behaviour. Calvo-Enrique, L., Lisa, S., Vicente-GarcÃa, C., Deogracias, R., Arévalo, JC. Frontiers in Molecular Neuroscience 16, 1266983.
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Mechanisms controlling the expression and secretion of BDNF. Arévalo, JC., Deogracias, R. Biomolecules 13 (5), 789.
2022
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Origin, Development, and Synaptogenesis of Cortical Interneurons. Llorca, A., Deogracias, R. Frontiers in Neuroscience.
2020
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TrkB deubiquitylation by USP8 regulates receptor levels and BDNF-dependent neuronal differentiation. MartÃn-RodrÃguez, C., Song, M., Anta, B., González-Calvo, FJ., Deogracias, R., Jing, D., Lee, FS., Arévalo, JC. Journal of Cell Science.
Publicaciones destacadas (Trayectoria previa) / Key Publications (Career Highlights)
2019
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Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits. *Deogracias, R. , Favuzzi, E.*, Marques-Smith, A., Maeso, P., Jezequel, J., Exposito-Alonso, D., Balia, M., Kroon, T., Hinojosa, AJ., Maraver, EF., Rico, B. (*Equal contribution). Science.
2018
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The Microtubule Regulator NEK7 Coordinates the Wiring of Cortical Parvalbumin Interneurons. Hinojosa, AJ., Deogracias, R., Rico, B. Cell Reports.
2017
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Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican. Favuzzi, E., *Deogracias, R. , Marques-Smith, A.*, Winterflood, CM., Sánchez-Aguilera, A., Mantoan, L., Maeso, P., Fernandes, C., Ewers, H., Rico, B. (*Equal contribution). Neuron.
2012
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Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome. *Deogracias, R. , Yazdani, M.*, Dekkers, MP., Guy, J., Ionescu, MC., Vogt, KE., Barde, YA. (*Equal contribution). PNAS.
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Seizure-induced neuronal death is suppressed in the absence of the endogenous lectin Galectin1. *Deogracias, R. , Bischoff, V., Poirier, F., Barde, YA. (*Equal contribution). Journal of Neuroscience.
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Disease modeling using embryonic stem cells: MeCP2 regulates nuclear size and RNA synthesis in neurons. *Deogracias, R. , Yazdani, M.*, Guy, J., Poot, RA., Bird, A., Barde, YA. (*Equal contribution). Stem Cells.
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Target genes of Topoisomerase IIβ regulate neuronal survival and are defined by their chromatin state. Tiwari, W., Burger, L.#, Nikoletopoulou, V.#, Deogracias, R., Wirbelauer, C., Murr, R., Terranova, R., Mielke, C., Boege, F., Lyu, Y-L., Peters, A., Barde, YA., Schübeler, D. (#Equal contribution). PNAS.
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BDNF and its pro-peptide are stored in presynaptic large dense core vesicles in brain neurons. Dieni, S., Matsumoto, T., Dekkers, M., Rauskolb, S., Ionescu, M., Deogracias, R., Gundelfinger, E-D., Kojima, M., Nestel, S., Frotscher, M., Barde, YA. The Journal of Cell Biology.
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Imbalance of neurotrophin receptor isoforms TrkB-FL/TrkB-T1 induces neuronal death in excitotoxicity. Vidaurre, O-G.#, Gascón, S.#, Deogracias, R., Sobrado, M., Cuadrado, E., Montaner, J., RodrÃguez-Peña, A., DÃaz-Guerra, M. (#Equal contribution). Cell Death and Disease.
2010
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Global deprivation of brain-derived neurotrophic factor in the CNS reveals an area-specific requirement for dendritic growth. Rauskolb, S., Zagrebelsky, M., Dreznjak, A., Deogracias, R., Matsumoto, T., Wiese, S., Erne, B., Sendtner, M., Schaeren-Wiemers, K., Korte, M., Barde, YA. Journal of Neuroscience.
2005
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Transcription of the NR1 subunit of the N-methyl-D-aspartate receptor is down-regulated by excitotoxic stimulation and cerebral ischemia. Gascón, S., Deogracias, R., Sobrado, M., Roda, JM., Renart, J., RodrÃguez-Peña, A., DÃaz-Guerra, M. The Journal of Biological Chemistry.
2004
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Expression of the neurotrophin receptor TrkB is regulated by the cAMP/CREB pathway in neurons. Deogracias, R., Espliguero, G., Iglesias, T., RodrÃguez-Peña, A. Molecular and Cellular Neuroscience.
